MAG and HEATMAG Streamlining magnetic bead purifications
Streamlining magnetic bead purifications
We have introduced the MAG and HEATMAG modules with you, the scientists, in mind. These cutting-edge solutions streamline magnetic bead purification in a broad range of molecular and proteomics workflows. The powerful magnets ensure fast bead collection with minimal loss and carryover, and their adjustable height can be customized to your volume requirements for optimal results every time. But that's not all; the HEATMAG module goes one step further by combining magnetic separation with heating capabilities, providing the perfect setting for nucleic acid extraction. It's a truly unique solution that sets INTEGRA apart from the rest.
The MAG and HEATMAG modules offer versatility like never before; they can be seamlessly integrated with our pipetting platforms for semi or fully automated workflows, or used as standalone units for manual processing, depending on your requirements. Combining them with the VIAFLO 96, MINI 96 or VIAFLO 384 pipetting platforms will enable you to process 96 or 384 well plates, or 24 tubes, simultaneously, significantly boosting your productivity. With the ASSIST PLUS pipetting robot, the MAG and HEATMAG modules provide full walk-away magnetic bead purification without the need for costly grippers and robotic arms. This combination opens up new possibilities for your laboratory, making it easier than ever to achieve high quality results.
In summary, the key benefits of the MAG and HEATMAG modules are:
- Adjustable magnet heights for bead collection, depending on the volume.
- Exceptional magnet strength, ensuring minimal bead carryover and maximum yields.
- HEATMAG offers a unique combination of magnetic engagement and heating capabilities for lysis or elution.
- Easy integration with the VIAFLO 96, MINI 96 or VIAFLO 384 pipetting platforms.
- Full automation when combined with the ASSIST PLUS pipetting robot.
How it works
MAG modules enable automated bead collection using hands-free vertical magnet movement.
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Overview
![Overview of the HEATMAG module on an ASSIST PLUS]()
- Strong magnet for minimal bead loss. The magnetic array can be exchanged on the MAG modules.
- Automated bead collection using vertical magnet movement.
- Different labware formats, such as tubes or plates, can be processed.
- Magnetic bead purification workflows can be fully automated using the ASSIST PLUS pipetting robot.
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Fast bead capture
![Top shot of a PCR adapter with magnets engaged]()
Hands-free vertical movement of a strong magnetic array and adjustable bead collection height result in high yields. This enables automated bead collection and optimal magnetic bead capture at both low and high volumes.
Users can switch between different preset heights when using it manually, or benefit from full workflow automation on the ASSIST PLUS pipetting robot.
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Heating and magnetic separation in one
![the HEATMAG module with an heating icon]()
HEATMAG combines magnets and heating in one device, supporting workflows at temperatures of up to 65 °C. This unique capability is crucial for tasks like lysis or elution
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Versatility
![MAG Module and all compatible labware adapters]()
The modules are compatible with a variety of labware types, providing added versatility for a wide range of applications.
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Boost productivity for magnetic bead applications
![All INTEGRA instruments you can use with the MAG and HEATMAG modules]()
Integration of MAG modules with the ASSIST PLUS pipetting robot allows fully automated, walk-away sample processing, optimizing workflow efficiency and boosting productivity in magnetic bead purification protocols.
Combining the modules with the MINI 96, VIAFLO 96 or VIAFLO 384 enables the simultaneous processing of 96 or 384 wells, or 24 tubes, for high throughput magnetic bead clean-up.
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Experience intuitive user interaction
![Experience intuitive user interaction]()
Explore seamless automation with the ASSIST PLUS pipetting robot and VIALAB pipetting software, for effortless control of the MAG modules.To use the modules in combination with the MINI 96, VIAFLO 96, or VIAFLO 384, or on their own, simply connect them to a computer via a USB connection for easy customization, or install the Communication Module to enable Bluetooth communication with the MAG Control App on mobile devices.
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See it work
Uses and Applications
Applications
- PCR clean-up
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PCR clean-up
PCR product purification using magnetic beads for efficient cleanup
Clean-up of reaction mixes after PCR protocols is essential to remove unincorporated primers or dNTPs, so that they do not disrupt subsequent reactions. The MAG module’s adapter for 96 or 384 well PCR plates enables hands-free PCR clean-ups for up to 384 simultaneous reactions per run.
![MAG VIAFLO 384 in 3 position stage]()
- NGS library clean-up
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NGS library clean-up
Single-size and double size selection in NGS library preparation
Magnetic beads efficiently isolate DNA fragments based on their size, which is crucial for both single- and double-size selection in NGS library preparation. Magnetic bead purifications with the MAG modules, combined with the precision of INTEGRA's pipetting platforms, provide high yields with minimal bead loss.
![MAG module PCR adapter on ASSIST PLUS]()
- Nucleic acid extraction
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Nucleic acid extraction
Magnetic beads simplify nucleic acid extraction, isolating DNA and RNA effectively
Isolation of nucleic acids requires selective binding of DNA or RNA from complex biological samples. Magnetic beads offer scalability in in nucleic acid extraction for both volumes and sample numbers. The bead collection height can be changed between the steps, allowing collection at optimal heights during binding/washing (volumes >500 µl) or elution steps (volumes <200 µl). In some extraction protocols, processing steps like lysis and elution require elevated temperatures; the combination of the HEATMAG module’s heating element with the adapter for 1.5 ml tubes is ideal for nucleic acid extractions.
![MAG module on a VIAFLO 384 with 24 wells]()
- Protein enrichment
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Protein enrichment
Concentration of specific proteins in a biological sample using magnetic beads.
The surface of the magnetic beads can also be functionalized with specific ligands – e.g. antibodies for immunoprecipitations – for use in protein analysis. These ligands are chosen to have a high affinity for the target proteins of interest. Repetitive manual pipetting steps can be minimized by combining MAG modules with INTEGRA's pipetting platforms, providing more hands-free time.
![HEATMAG module with a 1.5ml tube adapter on an ASSIST PLUS]()
Tech info
Find here a quick overview of the product specifications. More detailed information can be found in the download-section below.
- Dimensions (W x D x H)
- MAG: 133 mm x 88.5 mm x 70 mm (5.23 x 3.48 x 2.75 '') — HEATMAG: 133 mm x 88.5 mm x 73 mm (5.23 x 3.48 x 2.87 '')
- Operating Conditions
- Temperature: 5 to 40 °C — Humidity: <80 %
- Weight
- MAG: 1.0 kg (2.2 lbs) — HEATMAG: 1.1 kg (2.4 lbs)
- Power Requirements
- 100-240 VAC, 50/60 Hz, device input: 24 V, 120 W
Downloads & More
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Operating - Instructions MAG and HEATMAG ( 1.52 MB ) -
Flyer - Magnetic separation, heating, cooling and shaking ( 3.02 MB ) -
Quick Start Guide MAG and HEATMAG ( 261.27 KB ) -
MAG Control for Windows v.1.0.0.0 ( 29.69 MB ) -
MAG Control - App Store ( ) -
MAG Control - Google Play Store ( ) -
製品価格表2024年度第2版 ( 2.05 MB )
Parts and numbers
- Instrument
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Instrument
MAG and HEATMAG modules
Description Part No. MAG module for magnetic separation 4900 HEATMAG module for heating and magnetic separation 4901 - Accessories
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Accessories
Labware adapters and magnetic arrays
Description Part No. Adapter for 1.5 ml tubes, 4 x 6 format (MAG / HEATMAG) 4905 Adapter for 96 well PCR plate (MAG /HEATMAG) 4906 Adapter and magnetic array for 384 well PCR plate (MAG) 4908 Pedestal (+50 mm) 4963 Recommended liquid handling instrument to access the tubes and wells
Labware Compatible modules Standalone use with VIAFLO and VOYAGER ASSIST PLUS with VIAFLO and VOYAGER VIAFLO 96 and VIAFLO 384 MINI 96 1.5 ml micro-centrifuge tubes MAG
HEATMAG4 or 6 channel
VOYAGER
(10-1250 µl)4 or 6 channel
VOYAGER
(10-1250 µl)24 channel head
(10-1250 µl)96 well
PCR platesMAG
HEATMAG8 or 12 channel
VIAFLO/VOYAGER
(0.5-1250 µl)8 or 12 channel
VIAFLO/VOYAGER
(0.5-1250 µl)96 channel head
(0.5-1250 µl)MINI 96
all volumes384 well
PCR platesMAG 16 channel
VIAFLO
(0.5-125 µl)16 channel
VIAFLO
(0.5-125 µl)96 or 384 channel head
(0.5-125 µl)-----
- Control
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Control
Software to adjust settings or run MAG and HEATMAG
Description Part No. Communication module for MAG modules 4222 MAG Control for PC/laptop free download MAG Control app for mobile devices VIALAB more about VIALAB VIALINK more about VIALINK Download our MAG Control app for your mobile device:
- ASSIST PLUS and D-ONE
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ASSIST PLUS and D-ONE
Please visit ASSIST PLUS pipetting robot and D-ONE single channel pipetting module.
- VIAFLO and VOYAGER electronic pipettes
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VIAFLO and VOYAGER electronic pipettes
Please visit VIAFLO lightweight electronic pipettes and VOYAGER adjustable tip spacing pipette.
- 96 channel electronic pipettes
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96 channel electronic pipettes
Please visit MINI 96 and VIAFLO 96 and VIAFLO 384 electronic pipettes.
