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Streamline NGS size selection and PCR purification with MAGFLO™ magnetic beads

PCR purification and NGS size selection are crucial steps in molecular biology workflows, directly impacting the accuracy and efficiency of downstream applications. However, transforming samples into purified nucleic acids is frequently hindered by low yields, contamination and inaccurate size selection. We have recently launched MAGFLO magnetic beads to overcome these challenges. Their dynamic particle mobility allows efficient mixing, and their enhanced nucleic acid binding capacity ensures superior yields, all while sidestepping the need for tedious centrifugation steps. Best of all, MAGFLO magnetic beads can be used in combination with our MAG and HEATMAG modules for magnetic separation, as well as our benchtop pipetting platforms, for complete, end-to-end nucleic acid handling solutions that offer more walk-away time and increase productivity. We have leveraged our expertise in liquid handling and bead clean-up to provide reagents that are seamlessly compatible with our hardware for complete success.

MAGFLO magnetic beads provide precise and accurate nucleic acid fragment isolation, helping to ensure high recovery and maximum purity for NGS size selection (MAGFLO NGS) and PCR clean-up protocols (MAGFLO PCR). The standardized bead-to-sample ratio enables excellent results even in complex workflows – such as double-sided size selection – and the reagents are automation friendly to provide streamlined, hands-free and reproducible workflows. MAGFLO magnetic beads can also be combined with our VIAFLO 96/VIAFLO 384 handheld electronic pipettes or ASSIST PLUS pipetting robot and MAG or HEATMAG modules to provide users with a complete, end-to-end nucleic acid preparation solution from a single provider. Predefined pipetting programs enable hands-free magnetic bead clean-up with minimal set-up time, increasing both lab productivity and the reliability of results.

Magnetic beads tube

Applications for MAGFLO magnetic beads

Reliable NGS size selection

MAGFLO NGS magnetic beads provide a reliable solution for consistent target fragment size selection and distribution, which is essential for NGS library preparation workflows. Their precise bead-to-sample ratios simplify target size selection to efficiently isolate specific nucleic acid fragment sizes, and they are RNase free, making them the ideal choice for both DNA and RNA workflows. Interchangeable with gold standard beads, MAGFLO NGS magnetic beads provide identical single- and double-sided size selection results, making them a cost-effective alternative for any lab.

Effortless PCR purification

MAGFLO PCR beads are designed for PCR purification protocols. Their simple, three-step protocol efficiently removes unincorporated dNTPs, excess primers, primer dimers, salts and enzymes, ensuring a high amplicon recovery rate, particularly for those larger than 100 bp. Automation of this process enhances reproducibility, with no need for centrifugation or filtration, enabling faster protocols.

MAGFLO magnetic beads

Your end-to-end automated solution

Seamlessly combine the MAGFLO magnetic beads with the MAG and HEATMAG modules for efficient and reliable magnetic separation of nucleic acids. These modules use vertical magnet movements to automate bead collection, eliminating the need for manual plate transfers to reduce the risk of spills and allowing the collection of beads at various heights in the well. Add our advanced pipetting platforms – such as the ASSIST PLUS, VIAFLO 96 or VIAFLO 384 – to this winning combination to enable semi- or fully automated workflows, eliminating errors and optimizing productivity.

Dr Dagmara Lewandowska, Product Manager of Reagents at INTEGRA Biosciences, said: “The addition of the MAGFLO magnetic beads to our product portfolio – alongside our MAG, HEATMAG and pipetting solutions – provides users with a choice of comprehensive packages for nucleic acid purification. These innovative magnetic beads are interchangeable with the gold standard beads, and offer excellent reproducibility for consistent results, empowering scientists in their research pursuits.”

ASSIST PLUS transfers beads to PCR plate mag

Interested in learning more about our MAGFLO beads? Request a demo.

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